Advertisement
Table of Contents

October 2007

Cover

Individualization of Drosophila spermatids.
Issue Image

Drosophila spermatids are shown during an advanced stage of the morphogenetic process of "individualization." The apoptosis-like process of spermatid individualization—which separates the connections between developing spermatids-removes unneeded organelles and excess cytoplasm, thereby promoting major changes of the cytoarchitecture. This process requires cell death proteins, including apoptotic effector caspases (activated effector caspase is visualized by green staining). The tails of the individualizing spermatids are labeled with an antibody for polyglycylated axonemal tubulin (blue staining). The expelled cytoplasm and organelles are collected into a membrane-enclosed structure known as the "cystic bulge" or "waste bag" (marked by the red filament staining of the individualization complex). See Arama et al., e251.

Image Credit: This image was taken with a Zeiss confocal microscope by Eli Arama

Editorial

When Is Open Access Not Open Access?

Catriona J MacCallum

PLOS Biology: published October 16, 2007 | https://doi.org/10.1371/journal.pbio.0050285

Synopses

A New Human Genome Sequence Paves the Way for Individualized Genomics

Liza Gross

PLOS Biology: published September 4, 2007 | https://doi.org/10.1371/journal.pbio.0050266

Related Articles

  1. The Diploid Genome Sequence of an Individual Human

Completing the Candida Loop

Kira O'Day

PLOS Biology: published September 18, 2007 | https://doi.org/10.1371/journal.pbio.0050270

Related Articles

  1. Interlocking Transcriptional Feedback Loops Control White-Opaque Switching in Candida albicans

A Protein Complex Restrains a Homicidal Enzyme during Sperm Differentiation

Liza Gross

PLOS Biology: published September 18, 2007 | https://doi.org/10.1371/journal.pbio.0050279

Related Articles

  1. A Ubiquitin Ligase Complex Regulates Caspase Activation During Sperm Differentiation in Drosophila

Let Sleeping Zebrafish Lie: A New Model for Sleep Studies

Rachel Jones

PLOS Biology: published October 16, 2007 | https://doi.org/10.1371/journal.pbio.0050281

Related Articles

  1. Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants

Essay

Viral Evolution in the Genomic Age

Edward C Holmes

PLOS Biology: published October 2, 2007 | https://doi.org/10.1371/journal.pbio.0050278

Primer

Understanding Cannabinoid Psychoactivity with Mouse Genetic Models

Ken Mackie

PLOS Biology: published October 9, 2007 | https://doi.org/10.1371/journal.pbio.0050280

Related Articles

  1. Genetic Dissection of Behavioural and Autonomic Effects of Δ9-Tetrahydrocannabinol in Mice

Community Page

The NISE Net: Bringing the Study of the Very Small to US Science Centers

Margaret Glass

PLOS Biology: published October 16, 2007 | https://doi.org/10.1371/journal.pbio.0050283

Research Articles

The Diploid Genome Sequence of an Individual Human

Samuel Levy, Granger Sutton, Pauline C Ng, Lars Feuk, Aaron L Halpern, Brian P Walenz, Nelson Axelrod, Jiaqi Huang, Ewen F Kirkness, Gennady Denisov, Yuan Lin, Jeffrey R MacDonald, Andy Wing Chun Pang, Mary Shago, Timothy B Stockwell, Alexia Tsiamouri, Vineet Bafna, Vikas Bansal, Saul A Kravitz, Dana A Busam, Karen Y Beeson, Tina C McIntosh, Karin A Remington, Josep F Abril, John Gill, Jon Borman, Yu-Hui Rogers, Marvin E Frazier, Stephen W Scherer, Robert L Strausberg, J. Craig Venter

PLOS Biology: published September 4, 2007 | https://doi.org/10.1371/journal.pbio.0050254

Related Articles

  1. A New Human Genome Sequence Paves the Way for Individualized Genomics

Chromatin Structure Regulates Gene Conversion

W. Jason Cummings, Munehisa Yabuki, Ellen C Ordinario, David W Bednarski, Simon Quay, Nancy Maizels

PLOS Biology: published September 18, 2007 | https://doi.org/10.1371/journal.pbio.0050246

A Novel Snf2 Protein Maintains trans-Generational Regulatory States Established by Paramutation in Maize

Christopher J Hale, Jennifer L Stonaker, Stephen M Gross, Jay B Hollick

PLOS Biology: published October 16, 2007 | https://doi.org/10.1371/journal.pbio.0050275

Interlocking Transcriptional Feedback Loops Control White-Opaque Switching in Candida albicans

Rebecca E Zordan, Mathew G Miller, David J Galgoczy, Brian B Tuch, Alexander D Johnson

PLOS Biology: published September 18, 2007 | https://doi.org/10.1371/journal.pbio.0050256

Related Articles

  1. Completing the Candida Loop

Salmonella enterica Serovar Typhimurium Exploits Inflammation to Compete with the Intestinal Microbiota

Bärbel Stecher, Riccardo Robbiani, Alan W Walker, Astrid M Westendorf, Manja Barthel, Marcus Kremer, Samuel Chaffron, Andrew J Macpherson, Jan Buer, Julian Parkhill, Gordon Dougan, Christian von Mering, Wolf-Dietrich Hardt

PLOS Biology: published August 28, 2007 | https://doi.org/10.1371/journal.pbio.0050244

BDCA2/FcεRIγ Complex Signals through a Novel BCR-Like Pathway in Human Plasmacytoid Dendritic Cells

Wei Cao, Li Zhang, David B Rosen, Laura Bover, Gokuran Watanabe, Musheng Bao, Lewis L Lanier, Yong-Jun Liu

PLOS Biology: published September 11, 2007 | https://doi.org/10.1371/journal.pbio.0050248

Nanosensor Detection of an Immunoregulatory Tryptophan Influx/Kynurenine Efflux Cycle

Thijs Kaper, Loren L Looger, Hitomi Takanaga, Michael Platten, Lawrence Steinman, Wolf B Frommer

PLOS Biology: published September 25, 2007 | https://doi.org/10.1371/journal.pbio.0050257

Conformational Motion of the ABC Transporter MsbA Induced by ATP Hydrolysis

Peter P Borbat, Kavitha Surendhran, Marco Bortolus, Ping Zou, Jack H Freed, Hassane S Mchaourab

PLOS Biology: published October 9, 2007 | https://doi.org/10.1371/journal.pbio.0050271

Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD+

Wolfram Tempel, Wael M Rabeh, Katrina L Bogan, Peter Belenky, Marzena Wojcik, Heather F Seidle, Lyudmila Nedyalkova, Tianle Yang, Anthony A Sauve, Hee-Won Park, Charles Brenner

PLOS Biology: published October 2, 2007 | https://doi.org/10.1371/journal.pbio.0050263

Global Analysis of Posttranslational Protein Arginylation

Catherine C. L Wong, Tao Xu, Reena Rai, Aaron O Bailey, John R Yates 3rd, Yuri I Wolf, Henry Zebroski, Anna Kashina

PLOS Biology: published September 25, 2007 | https://doi.org/10.1371/journal.pbio.0050258

Force-Induced Unfolding of Fibronectin in the Extracellular Matrix of Living Cells

Michael L Smith, Delphine Gourdon, William C Little, Kristopher E Kubow, R. Andresen Eguiluz, Sheila Luna-Morris, Viola Vogel

PLOS Biology: published October 2, 2007 | https://doi.org/10.1371/journal.pbio.0050268

Assessing Tumor Progression Factors by Somatic Gene Transfer into a Mouse Model: Bcl-xL Promotes Islet Tumor Cell Invasion

Yi-Chieh Nancy Du, Brian C Lewis, Douglas Hanahan, Harold Varmus

PLOS Biology: published October 16, 2007 | https://doi.org/10.1371/journal.pbio.0050276

A Ubiquitin Ligase Complex Regulates Caspase Activation During Sperm Differentiation in Drosophila

Eli Arama, Maya Bader, Gabrielle E Rieckhof, Hermann Steller

PLOS Biology: published September 18, 2007 | https://doi.org/10.1371/journal.pbio.0050251

Related Articles

  1. A Protein Complex Restrains a Homicidal Enzyme during Sperm Differentiation
  2. Correction: A Ubiquitin Ligase Complex Regulates Caspase Activation During Sperm Differentiation in Drosophila

X Chromosome Inactivation during Drosophila Spermatogenesis

Winfried Hense, John F Baines, John Parsch

PLOS Biology: published October 9, 2007 | https://doi.org/10.1371/journal.pbio.0050273

Negative Autoregulation by FAS Mediates Robust Fetal Erythropoiesis

Merav Socolovsky, Michael Murrell, Ying Liu, Ramona Pop, Ermelinda Porpiglia, Andre Levchenko

PLOS Biology: published September 25, 2007 | https://doi.org/10.1371/journal.pbio.0050252

Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development, and Life Extension in Caenorhabditis elegans

Shane L Rea, Natascia Ventura, Thomas E Johnson

PLOS Biology: published October 2, 2007 | https://doi.org/10.1371/journal.pbio.0050259

Related Articles

  1. Correction: Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development, and Life Extension in Caenorhabditis elegans
  2. Correction: Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development, and Life Extension in Caenorhabditis elegan
  3. Correction: Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development and Life Extension in Caenorhabditis elegans

MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae

Oliver Medvedik, Dudley W Lamming, Keyman D Kim, David A Sinclair

PLOS Biology: published October 2, 2007 | https://doi.org/10.1371/journal.pbio.0050261

Drug-Induced Epigenetic Changes Produce Drug Tolerance

Yan Wang, Harish R Krishnan, Alfredo Ghezzi, Jerry C. P Yin, Nigel S Atkinson

PLOS Biology: published October 16, 2007 | https://doi.org/10.1371/journal.pbio.0050265

Genetic Dissection of Behavioural and Autonomic Effects of Δ9-Tetrahydrocannabinol in Mice

Krisztina Monory, Heike Blaudzun, Federico Massa, Nadine Kaiser, Thomas Lemberger, Günther Schütz, Carsten T Wotjak, Beat Lutz, Giovanni Marsicano

PLOS Biology: published October 9, 2007 | https://doi.org/10.1371/journal.pbio.0050269

Related Articles

  1. Understanding Cannabinoid Psychoactivity with Mouse Genetic Models

Hypoinsulinemia Regulates Amphetamine-Induced Reverse Transport of Dopamine

Jason M Williams, W. Anthony Owens, Gregory H Turner, Christine Saunders, Concetta Dipace, Randy D Blakely, Charles P France, John C Gore, Lynette C Daws, Malcolm J Avison, Aurelio Galli

PLOS Biology: published October 16, 2007 | https://doi.org/10.1371/journal.pbio.0050274

Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants

Tohei Yokogawa, Wilfredo Marin, Juliette Faraco, Guillaume Pézeron, Lior Appelbaum, Jian Zhang, Frédéric Rosa, Philippe Mourrain, Emmanuel Mignot

PLOS Biology: published October 16, 2007 | https://doi.org/10.1371/journal.pbio.0050277

Related Articles

  1. Let Sleeping Zebrafish Lie: A New Model for Sleep Studies

Segregation of Odor Identity and Intensity during Odor Discrimination in Drosophila Mushroom Body

Shouzhen Xia, Tim Tully

PLOS Biology: published October 2, 2007 | https://doi.org/10.1371/journal.pbio.0050264

Brain Dynamics Underlying the Nonlinear Threshold for Access to Consciousness

Antoine Del Cul, Sylvain Baillet, Stanislas Dehaene

PLOS Biology: published September 25, 2007 | https://doi.org/10.1371/journal.pbio.0050260

Putting Beta-Diversity on the Map: Broad-Scale Congruence and Coincidence in the Extremes

Meghan W McKnight, Peter S White, Robert I McDonald, John F Lamoreux, Wes Sechrest, Robert S Ridgely, Simon N Stuart

PLOS Biology: published October 9, 2007 | https://doi.org/10.1371/journal.pbio.0050272