April 2007

An embryo of the cnidarian Clytia hemisphaerica fixed during gastrulation, showing cell boundaries (red), nuclei (blue), and cilia (green). Two distinct Frizzled family receptors produced from RNAs with opposite localizations in the egg provide the spatial cues to specify the gastrulation site and the polarized orientation of the cilia (see Momose and Houliston, e70).

Image Credit: Confocal image by Tsuyoshi Momose

Editorial

Does Medicine without Evolution Make Sense?

Catriona J MacCallum

PLOS Biology: published April 17, 2007 | https://doi.org/10.1371/journal.pbio.0050112

Synopses

Paradox Resolved? The Strange Case of the Radiation-Resistant Bacteria

Liza Gross

PLOS Biology: published March 20, 2007 | https://doi.org/10.1371/journal.pbio.0050108

From One to Many and Back Again: A Systemic Signal Triggers Tunicate Regeneration

Liza Gross

PLOS Biology: published March 6, 2007 | https://doi.org/10.1371/journal.pbio.0050098

Who Needs Sex (or Males) Anyway?

Liza Gross

PLOS Biology: published March 20, 2007 | https://doi.org/10.1371/journal.pbio.0050099

In the Shadows of the Congo Basin Forest, Elephants Fall to the Illegal Ivory Trade

Liza Gross

PLOS Biology: published April 3, 2007 | https://doi.org/10.1371/journal.pbio.0050115

Essays

The Genetics of Brain Wiring: From Molecule to Mind

Kevin J Mitchell

PLOS Biology: published April 17, 2007 | https://doi.org/10.1371/journal.pbio.0050113

Law, Responsibility, and the Brain

Dean Mobbs, Hakwan C Lau, Owen D Jones, Christopher D Frith

PLOS Biology: published April 17, 2007 | https://doi.org/10.1371/journal.pbio.0050103

Research Articles

H2A.Z-Mediated Localization of Genes at the Nuclear Periphery Confers Epigenetic Memory of Previous Transcriptional State

Donna Garvey Brickner, Ivelisse Cajigas, Yvonne Fondufe-Mittendorf, Sara Ahmed, Pei-Chih Lee, Jonathan Widom, Jason H Brickner

PLOS Biology: published March 20, 2007 | https://doi.org/10.1371/journal.pbio.0050081

An Aromatic Sensor with Aversion to Damaged Strands Confers Versatility to DNA Repair

Olivier Maillard, Szilvia Solyom, Hanspeter Naegeli

PLOS Biology: published March 13, 2007 | https://doi.org/10.1371/journal.pbio.0050079

Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon

Yimin Hua, Timothy A Vickers, Brenda F Baker, C. Frank Bennett, Adrian R Krainer

PLOS Biology: published March 13, 2007 | https://doi.org/10.1371/journal.pbio.0050073

Transcript Specificity in Yeast Pre-mRNA Splicing Revealed by Mutations in Core Spliceosomal Components

Jeffrey A Pleiss, Gregg B Whitworth, Megan Bergkessel, Christine Guthrie

PLOS Biology: published March 27, 2007 | https://doi.org/10.1371/journal.pbio.0050090

Superfamily Assignments for the Yeast Proteome through Integration of Structure Prediction with the Gene Ontology

Lars Malmström, Michael Riffle, Charlie E. M Strauss, Dylan Chivian, Trisha N Davis, Richard Bonneau, David Baker

PLOS Biology: published March 20, 2007 | https://doi.org/10.1371/journal.pbio.0050076

Protein Oxidation Implicated as the Primary Determinant of Bacterial Radioresistance

Michael J Daly, Elena K Gaidamakova, Vera Y Matrosova, Alexander Vasilenko, Min Zhai, Richard D Leapman, Barry Lai, Bruce Ravel, Shu-Mei W Li, Kenneth M Kemner, James K Fredrickson

PLOS Biology: published March 20, 2007 | https://doi.org/10.1371/journal.pbio.0050092

Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation In Vivo

Véronique Calleja, Damien Alcor, Michel Laguerre, Jongsun Park, Borivoj Vojnovic, Brian A Hemmings, Julian Downward, Peter J Parker, Banafshé Larijani

PLOS Biology: published April 3, 2007 | https://doi.org/10.1371/journal.pbio.0050095

DNA-Dependent Protein Kinase Inhibits AID-Induced Antibody Gene Conversion

Adam J. L Cook, Joanna M Raftery, K. K. Edwin Lau, Andrew Jessup, Reuben S Harris, Shunichi Takeda, Christopher J Jolly

PLOS Biology: published March 13, 2007 | https://doi.org/10.1371/journal.pbio.0050080

Modification of a Hydrophobic Layer by a Point Mutation in Syntaxin 1A Regulates the Rate of Synaptic Vesicle Fusion

Robert D Lagow, Hong Bao, Evan N Cohen, Richard W Daniels, Aleksej Zuzek, Wade H Williams, Gregory T Macleod, R. Bryan Sutton, Bing Zhang

PLOS Biology: published March 6, 2007 | https://doi.org/10.1371/journal.pbio.0050072

Expanding the Neuron's Calcium Signaling Repertoire: Intracellular Calcium Release via Voltage-Induced PLC and IP3R Activation

Stefanie Ryglewski, Hans J Pflueger, Carsten Duch

PLOS Biology: published March 6, 2007 | https://doi.org/10.1371/journal.pbio.0050066

Fly Photoreceptors Demonstrate Energy-Information Trade-Offs in Neural Coding

Jeremy E Niven, John C Anderson, Simon B Laughlin

PLOS Biology: published March 20, 2007 | https://doi.org/10.1371/journal.pbio.0050116

Elucidating the Ticking of an In Vitro Circadian Clockwork

Tetsuya Mori, Dewight R Williams, Mark O Byrne, Ximing Qin, Martin Egli, Hassane S Mchaourab, Phoebe L Stewart, Carl Hirschie Johnson

PLOS Biology: published March 27, 2007 | https://doi.org/10.1371/journal.pbio.0050093

Glucocorticoids Play a Key Role in Circadian Cell Cycle Rhythms

Thomas Dickmeis, Kajori Lahiri, Gabriela Nica, Daniela Vallone, Cristina Santoriello, Carl J Neumann, Matthias Hammerschmidt, Nicholas S Foulkes

PLOS Biology: published March 20, 2007 | https://doi.org/10.1371/journal.pbio.0050078

Cdk5 Is Involved in BDNF-Stimulated Dendritic Growth in Hippocampal Neurons

Zelda H Cheung, Wing Hong Chin, Yu Chen, Yu Pong Ng, Nancy Y Ip

PLOS Biology: published March 6, 2007 | https://doi.org/10.1371/journal.pbio.0050063

The Prethalamus Is Established during Gastrulation and Influences Diencephalic Regionalization

Nicole Staudt, Corinne Houart

PLOS Biology: published March 6, 2007 | https://doi.org/10.1371/journal.pbio.0050069

Two Oppositely Localised Frizzled RNAs as Axis Determinants in a Cnidarian Embryo

Tsuyoshi Momose, Evelyn Houliston

PLOS Biology: published March 13, 2007 | https://doi.org/10.1371/journal.pbio.0050070

Systemic Bud Induction and Retinoic Acid Signaling Underlie Whole Body Regeneration in the Urochordate Botrylloides leachi

Yuval Rinkevich, Guy Paz, Baruch Rinkevich, Ram Reshef

PLOS Biology: published March 6, 2007 | https://doi.org/10.1371/journal.pbio.0050071

Independently Evolving Species in Asexual Bdelloid Rotifers

Diego Fontaneto, Elisabeth A Herniou, Chiara Boschetti, Manuela Caprioli, Giulio Melone, Claudia Ricci, Timothy G Barraclough

PLOS Biology: published March 20, 2007 | https://doi.org/10.1371/journal.pbio.0050087

Understanding the Evolutionary Fate of Finite Populations: The Dynamics of Mutational Effects

Olin K Silander, Olivier Tenaillon, Lin Chao

PLOS Biology: published April 3, 2007 | https://doi.org/10.1371/journal.pbio.0050094

Survey Sequencing and Comparative Analysis of the Elephant Shark (Callorhinchus milii) Genome

Byrappa Venkatesh, Ewen F Kirkness, Yong-Hwee Loh, Aaron L Halpern, Alison P Lee, Justin Johnson, Nidhi Dandona, Lakshmi D Viswanathan, Alice Tay, J. Craig Venter, Robert L Strausberg, Sydney Brenner

PLOS Biology: published April 3, 2007 | https://doi.org/10.1371/journal.pbio.0050101

Forest Elephant Crisis in the Congo Basin

Stephen Blake, Samantha Strindberg, Patrick Boudjan, Calixte Makombo, Inogwabini Bila-Isia, Omari Ilambu, Falk Grossmann, Lambert Bene-Bene, Bruno de Semboli, Valentin Mbenzo, Dino S'hwa, Rosine Bayogo, Liz Williamson, Mike Fay, John Hart, Fiona Maisels

PLOS Biology: published April 3, 2007 | https://doi.org/10.1371/journal.pbio.0050111