November 2006

A dynamic tuning process restricts the responsiveness of autoreactive T cells, but its relative inefficiency in abrogating effector functionality results in arthritis and autoantibody production (bottom panels). Singh et al. examine the separable contributions of intrinsic and extrinsic regulatory processes to the control of peripheral autoimmunity.

Image Credit: Nevil Singh

Editorial

ONE for All: The Next Step for PLoS

Catriona J MacCallum

PLOS Biology: published November 14, 2006 | https://doi.org/10.1371/journal.pbio.0040401

Essay

Bushes in the Tree of Life

Antonis Rokas, Sean B Carroll

PLOS Biology: published November 14, 2006 | https://doi.org/10.1371/journal.pbio.0040352

Primer

A Marriage of Old and New: Chemostats and Microarrays Identify a New Model System for Ammonium Toxicity

Michael C Lorenz

PLOS Biology: published November 14, 2006 | https://doi.org/10.1371/journal.pbio.0040388

Community Page

BioGeomancer: Automated Georeferencing to Map the World's Biodiversity Data

Robert P Guralnick, John Wieczorek, Reed Beaman, Robert J Hijmans, the BioGeomancer Working Group

PLOS Biology: published November 14, 2006 | https://doi.org/10.1371/journal.pbio.0040381

Research Articles

The Testis-Specific Factor CTCFL Cooperates with the Protein Methyltransferase PRMT7 in H19 Imprinting Control Region Methylation

Petar Jelinic, Jean-Christophe Stehle, Phillip Shaw

PLOS Biology: published October 17, 2006 | https://doi.org/10.1371/journal.pbio.0040355

Two-Step Recruitment of RNA-Directed DNA Methylation to Tandem Repeats

Simon W.-L Chan, Xiaoyu Zhang, Yana V Bernatavichute, Steven E Jacobsen

PLOS Biology: published October 24, 2006 | https://doi.org/10.1371/journal.pbio.0040363

Target DNA Structure Plays a Critical Role in RAG Transposition

Jennifer E Posey, Malgorzata J Pytlos, Richard R Sinden, David B Roth

PLOS Biology: published October 24, 2006 | https://doi.org/10.1371/journal.pbio.0040350

A Role for PCNA Ubiquitination in Immunoglobulin Hypermutation

Hiroshi Arakawa, George-Lucian Moldovan, Huseyin Saribasak, Nesibe Nur Saribasak, Stefan Jentsch, Jean-Marie Buerstedde

PLOS Biology: published October 24, 2006 | https://doi.org/10.1371/journal.pbio.0040366

The Impact of T Cell Intrinsic Antigen Adaptation on Peripheral Immune Tolerance

Nevil J Singh, Chuan Chen, Ronald H Schwartz

PLOS Biology: published October 17, 2006 | https://doi.org/10.1371/journal.pbio.0040340

Human Immunodeficiency Virus Impairs Reverse Cholesterol Transport from Macrophages

Zahedi Mujawar, Honor Rose, Matthew P Morrow, Tatiana Pushkarsky, Larisa Dubrovsky, Nigora Mukhamedova, Ying Fu, Anthony Dart, Jan M Orenstein, Yuri V Bobryshev, Michael Bukrinsky, Dmitri Sviridov

PLOS Biology: published October 31, 2006 | https://doi.org/10.1371/journal.pbio.0040365

Assembly Factor Omp85 Recognizes Its Outer Membrane Protein Substrates by a Species-Specific C-Terminal Motif

Viviane Robert, Elena B Volokhina, Freya Senf, Martine P Bos, Patrick Van Gelder, Jan Tommassen

PLOS Biology: published November 7, 2006 | https://doi.org/10.1371/journal.pbio.0040377

The Liganding of Glycolipid Transfer Protein Is Controlled by Glycolipid Acyl Structure

Lucy Malinina, Margarita L Malakhova, Alex T Kanack, Min Lu, Ruben Abagyan, Rhoderick E Brown, Dinshaw J Patel

PLOS Biology: published October 24, 2006 | https://doi.org/10.1371/journal.pbio.0040362

Ammonium Toxicity and Potassium Limitation in Yeast

David C Hess, Wenyun Lu, Joshua D Rabinowitz, David Botstein

PLOS Biology: published October 17, 2006 | https://doi.org/10.1371/journal.pbio.0040351

Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins

D. Thomas Rutkowski, Stacey M Arnold, Corey N Miller, Jun Wu, Jack Li, Kathryn M Gunnison, Kazutoshi Mori, Amir A. Sadighi Akha, David Raden, Randal J Kaufman

PLOS Biology: published November 7, 2006 | https://doi.org/10.1371/journal.pbio.0040374

Ablation of PGC-1β Results in Defective Mitochondrial Activity, Thermogenesis, Hepatic Function, and Cardiac Performance

Christopher J Lelliott, Gema Medina-Gomez, Natasa Petrovic, Adrienn Kis, Helena M Feldmann, Mikael Bjursell, Nadeene Parker, Keira Curtis, Mark Campbell, Ping Hu, Dongfang Zhang, Sheldon E Litwin, Vlad G Zaha, Kimberly T Fountain, Sihem Boudina, Mercedes Jimenez-Linan, Margaret Blount, Miguel Lopez, Aline Meirhaeghe, Mohammad Bohlooly-Y, Leonard Storlien, Maria Strömstedt, Michael Snaith, Matej Orešič, E. Dale Abel, Barbara Cannon, Antonio Vidal-Puig

PLOS Biology: published November 7, 2006 | https://doi.org/10.1371/journal.pbio.0040369

Plasticity of Astrocytic Coverage and Glutamate Transporter Expression in Adult Mouse Cortex

Christel Genoud, Charles Quairiaux, Pascal Steiner, Harald Hirling, Egbert Welker, Graham W Knott

PLOS Biology: published October 17, 2006 | https://doi.org/10.1371/journal.pbio.0040343

Rapid Redistribution of Synaptic PSD-95 in the Neocortex In Vivo

Noah W Gray, Robby M Weimer, Ingrid Bureau, Karel Svoboda

PLOS Biology: published November 7, 2006 | https://doi.org/10.1371/journal.pbio.0040370

A Signaling Network for Patterning of Neuronal Connectivity in the Drosophila Brain

Mohammed Srahna, Maarten Leyssen, Ching Man Choi, Lee G Fradkin, Jasprina N Noordermeer, Bassem A Hassan

PLOS Biology: published October 10, 2006 | https://doi.org/10.1371/journal.pbio.0040348

Intracellular Demography and the Dynamics of Salmonella enterica Infections

Sam P Brown, Stephen J Cornell, Mark Sheppard, Andrew J Grant, Duncan J Maskell, Bryan T Grenfell, Pietro Mastroeni

PLOS Biology: published October 17, 2006 | https://doi.org/10.1371/journal.pbio.0040349

Intralocus Sexual Conflict Diminishes the Benefits of Sexual Selection

Alison Pischedda, Adam K Chippindale

PLOS Biology: published October 24, 2006 | https://doi.org/10.1371/journal.pbio.0040356

Detecting Non-Brownian Trait Evolution in Adaptive Radiations

Robert P Freckleton, Paul H Harvey

PLOS Biology: published November 7, 2006 | https://doi.org/10.1371/journal.pbio.0040373

Phenotypic Plasticity Opposes Species Invasions by Altering Fitness Surface

Scott D Peacor, Stefano Allesina, Rick L Riolo, Mercedes Pascual

PLOS Biology: published October 31, 2006 | https://doi.org/10.1371/journal.pbio.0040372

The Marine Viromes of Four Oceanic Regions

Florent E Angly, Ben Felts, Mya Breitbart, Peter Salamon, Robert A Edwards, Craig Carlson, Amy M Chan, Matthew Haynes, Scott Kelley, Hong Liu, Joseph M Mahaffy, Jennifer E Mueller, Jim Nulton, Robert Olson, Rachel Parsons, Steve Rayhawk, Curtis A Suttle, Forest Rohwer

PLOS Biology: published November 7, 2006 | https://doi.org/10.1371/journal.pbio.0040368

Corrections

Correction: Morphological Evolution Is Accelerated among Island Mammals

Virginie Millien

PLOS Biology: published November 14, 2006 | https://doi.org/10.1371/journal.pbio.0040384

Correction: Preserving Genome Integrity: The DdrA Protein of Deinococcus radiodurans R1

Dennis R Harris, Masashi Tanaka, Sergei V Saveliev, Edmond Jolivet, Ashlee M Earl, Michael M Cox, John R Battista

PLOS Biology: published November 14, 2006 | https://doi.org/10.1371/journal.pbio.0040385

Cover

Arthritic limbs from mice with autoimmune disease.

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