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Table of Contents

January 2005

Cover

A cross section of abnormally thickened skin epidermis from Snail transgenic mice.
Issue Image

Epidermal thickening is seen in the skin of transgenic mice expressing the transcription factor Snail, as shown in this skin section. Expansion of basal and terminally differentiating layers occurs, as detected by antibodies against keratin 5 (green), which normally marks the innermost (basal) layer, and against filaggrin (red), a late-stage marker of upper layers. (See Jamora et al.)

Features

A Golden Age of Brain Exploration

Virginia Gewin

PLOS Biology: published January 18, 2005 | https://doi.org/10.1371/journal.pbio.0030024

Help Wanted: Science Manager

Kirsten A Hubbard

PLOS Biology: published January 18, 2005 | https://doi.org/10.1371/journal.pbio.0030032

Primer

Sex Determination across Evolution: Connecting the Dots

Eric S Haag, Alana V Doty

PLOS Biology: published January 18, 2005 | https://doi.org/10.1371/journal.pbio.0030021

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Community Pages

Biology by Numbers—Introducing Quantitation into Life Science Education

Tinri Aegerter-Wilmsen, Ton Bisseling

PLOS Biology: published January 18, 2005 | https://doi.org/10.1371/journal.pbio.0030001

Accessing the Microscopic World

Charles Carlson

PLOS Biology: published January 18, 2005 | https://doi.org/10.1371/journal.pbio.0030012

Research Articles

Aerial Surveys Give New Estimates for Orangutans in Sabah, Malaysia

Marc Ancrenaz, Olivier Gimenez, Laurentius Ambu, Karine Ancrenaz, Patrick Andau, Benoît Goossens, John Payne, Azri Sawang, Augustine Tuuga, Isabelle Lackman-Ancrenaz

PLOS Biology: published December 7, 2004 | https://doi.org/10.1371/journal.pbio.0030003

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  1. Tracking Orangutans from the Sky

Relaxed Molecular Clock Provides Evidence for Long-Distance Dispersal of Nothofagus (Southern Beech)

Michael Knapp, Karen Stöckler, David Havell, Frédéric Delsuc, Federico Sebastiani, Peter J Lockhart

PLOS Biology: published January 4, 2005 | https://doi.org/10.1371/journal.pbio.0030014

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  1. Dispersal or Drift? More to Plant Biodiversity Than Meets the Eye

Ancient DNA Provides New Insights into the Evolutionary History of New Zealand's Extinct Giant Eagle

Michael Bunce, Marta Szulkin, Heather R. L Lerner, Ian Barnes, Beth Shapiro, Alan Cooper, Richard N Holdaway

PLOS Biology: published January 4, 2005 | https://doi.org/10.1371/journal.pbio.0030009

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  1. Ancient DNA Tells Story of Giant Eagle Evolution

A Gradual Process of Recombination Restriction in the Evolutionary History of the Sex Chromosomes in Dioecious Plants

Michael Nicolas, Gabriel Marais, Vladka Hykelova, Bohuslav Janousek, Valérie Laporte, Boris Vyskot, Dominique Mouchiroud, Ioan Negrutiu, Deborah Charlesworth, Françoise Monéger

PLOS Biology: published December 21, 2004 | https://doi.org/10.1371/journal.pbio.0030004

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  1. Evolution of Sex Chromosomes: The Case of the White Campion

fog-2 and the Evolution of Self-Fertile Hermaphroditism in Caenorhabditis

Sudhir Nayak, Johnathan Goree, Tim Schedl

PLOS Biology: published December 28, 2004 | https://doi.org/10.1371/journal.pbio.0030006

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  1. The Evolution of Self-Fertile Hermaphroditism: The Fog Is Clearing
  2. Sex Determination across Evolution: Connecting the Dots

Major Structural Differences and Novel Potential Virulence Mechanisms from the Genomes of Multiple Campylobacter Species

Derrick E Fouts, Emmanuel F Mongodin, Robert E Mandrell, William G Miller, David A Rasko, Jacques Ravel, Lauren M Brinkac, Robert T DeBoy, Craig T Parker, Sean C Daugherty, Robert J Dodson, A. Scott Durkin, Ramana Madupu, Steven A Sullivan, Jyoti U Shetty, Mobolanle A Ayodeji, Alla Shvartsbeyn, Michael C Schatz, Jonathan H Badger, Claire M Fraser, Karen E Nelson

PLOS Biology: published January 4, 2005 | https://doi.org/10.1371/journal.pbio.0030015

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  1. Multiple Campylobacter Genomes Sequenced

The Structure of a Rigorously Conserved RNA Element within the SARS Virus Genome

Michael P Robertson, Haller Igel, Robert Baertsch, David Haussler, Manuel Ares Jr, William G Scott

PLOS Biology: published December 28, 2004 | https://doi.org/10.1371/journal.pbio.0030005

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  1. Structure of a Conserved RNA Element in the SARS Virus Genome Determined

A Model of the Statistical Power of Comparative Genome Sequence Analysis

Sean R Eddy

PLOS Biology: published January 4, 2005 | https://doi.org/10.1371/journal.pbio.0030010

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  1. Genome Sequencing: Using Models to Predict Who's Next

Sorghum Genome Sequencing by Methylation Filtration

Joseph A Bedell, Muhammad A Budiman, Andrew Nunberg, Robert W Citek, Dan Robbins, Joshua Jones, Elizabeth Flick, Theresa Rohlfing, Jason Fries, Kourtney Bradford, Jennifer McMenamy, Michael Smith, Heather Holeman, Bruce A Roe, Graham Wiley, Ian F Korf, Pablo D Rabinowicz, Nathan Lakey, W. Richard McCombie, Jeffrey A Jeddeloh, Robert A Martienssen

PLOS Biology: published January 4, 2005 | https://doi.org/10.1371/journal.pbio.0030013

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  1. Separating Wheat from Chaff in Plant Genomes

Highly Conserved Non-Coding Sequences Are Associated with Vertebrate Development

Adam Woolfe, Martin Goodson, Debbie K Goode, Phil Snell, Gayle K McEwen, Tanya Vavouri, Sarah F Smith, Phil North, Heather Callaway, Krys Kelly, Klaudia Walter, Irina Abnizova, Walter Gilks, Yvonne J. K Edwards, Julie E Cooke, Greg Elgar

PLOS Biology: published November 11, 2004 | https://doi.org/10.1371/journal.pbio.0030007

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  1. Unexpressed but Indispensable—The DNA Sequences That Control Development

A Signaling Pathway Involving TGF-β2 and Snail in Hair Follicle Morphogenesis

Colin Jamora, Pedro Lee, Pawel Kocieniewski, Mohamad Azhar, Ryoichi Hosokawa, Yang Chai, Elaine Fuchs

PLOS Biology: published December 28, 2004 | https://doi.org/10.1371/journal.pbio.0030011

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  1. Hirsute or Hairless? Two Proteins May Spell the Difference

Disentangling Sub-Millisecond Processes within an Auditory Transduction Chain

Tim Gollisch, Andreas M. V Herz

PLOS Biology: published January 4, 2005 | https://doi.org/10.1371/journal.pbio.0030008

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  1. Computation Provides a Virtual Recording of Auditory Signaling

Neuronal Encoding of Texture in the Whisker Sensory Pathway

Ehsan Arabzadeh, Erik Zorzin, Mathew E Diamond

PLOS Biology: published January 11, 2005 | https://doi.org/10.1371/journal.pbio.0030017

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  1. Whisker Velocity Patterns Tell Rats What They're Feeling

Transcription-Based Prediction of Response to IFNβ Using Supervised Computational Methods

Sergio E Baranzini, Parvin Mousavi, Jordi Rio, Stacy J Caillier, Althea Stillman, Pablo Villoslada, Matthew M Wyatt, Manuel Comabella, Larry D Greller, Roland Somogyi, Xavier Montalban, Jorge R Oksenberg

PLOS Biology: published December 28, 2004 | https://doi.org/10.1371/journal.pbio.0030002

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  1. Gene Signatures Predict Interferon Response for MS Patients
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Correction

Correction: Regulation of Muscle Fiber Type and Running Endurance by PPARδ

PLOS Biology: published January 18, 2005 | https://doi.org/10.1371/journal.pbio.0030061

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Book Review%2FScience in the Media

Turning to Science

Hemai Parthasarathy

PLOS Biology: published January 18, 2005 | https://doi.org/10.1371/journal.pbio.0030023