The cover depicts the structure of the newly-discovered, water-selective aquaporin AqpZ. Five water molecules are seen in the channel defining the conductance pathway. The painting represents a merging of science and mythology in which AqpZ traverses a membrane "sea" between the cytoplasmic underworld and an approaching rainstorm. (See Savage, et al.)
Image Credit: Painting by Julie Newdoll, www.brushwithscience.com. Ribbons created with PyMOL software
Editorial
A Changing Landscape
PLOS Biology: published December 22, 2003 | https://doi.org/10.1371/journal.pbio.0000089
Essay
The Virus That Changed My World
PLOS Biology: published December 22, 2003 | https://doi.org/10.1371/journal.pbio.0000066
Features
Economy of the Mind
PLOS Biology: published December 22, 2003 | https://doi.org/10.1371/journal.pbio.0000077
Human Epigenome Project—Up and Running
PLOS Biology: published December 22, 2003 | https://doi.org/10.1371/journal.pbio.0000082
Unsolved Mystery
How Are the Sizes of Cells, Organs, and Bodies Controlled?
PLOS Biology: published December 22, 2003 | https://doi.org/10.1371/journal.pbio.0000086
Journal Club
A Wingless Flight
PLOS Biology: published December 22, 2003 | https://doi.org/10.1371/journal.pbio.0000049
Primers
How Mammals Acquire and Distribute Iron Needed for Oxygen-Based Metabolism
PLOS Biology: published December 22, 2003 | https://doi.org/10.1371/journal.pbio.0000079
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Antigen-Specific T Cells: Analyses of the Needles in the Haystack
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Community Page
Research Advocacy: Why Every Scientist Should Participate
PLOS Biology: published December 22, 2003 | https://doi.org/10.1371/journal.pbio.0000071
Research Articles
Architecture and Selectivity in Aquaporins: 2.5 Å X-Ray Structure of Aquaporin Z
PLOS Biology: published December 22, 2003 | https://doi.org/10.1371/journal.pbio.0000072
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Mechanism for Multiple Ligand Recognition by the Human Transferrin Receptor
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Linkage of Osteoporosis to Chromosome 20p12 and Association to BMP2
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Transcriptome Analysis of Mouse Stem Cells and Early Embryos
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Distinct Mechanisms Determine Transposon Inheritance and Methylation via Small Interfering RNA and Histone Modification
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Corrections
Correction: What Controls Variation in Human Skin Color?
PLOS Biology: published December 22, 2003 | https://doi.org/10.1371/journal.pbio.0000091
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Correction: Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action
PLOS Biology: published December 22, 2003 | https://doi.org/10.1371/journal.pbio.0000092
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PLOS Biology: published December 22, 2003 | https://doi.org/10.1371/journal.pbio.0000073