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October 2003

The cover shows native Borneo elephants, which are now recognized as genetically distinct from other Asian elephants. The Borneo elephants are therefore a high priority for conservation. (See Fernando, et al.)

Image Credit: Photograph kindly provided by Cede Prudente, World Wildlife Fund, Malaysia

Message from the Founders

Why PLoS Became a Publisher

Patrick O Brown, Michael B Eisen, Harold E Varmus

Editorial

PLoS Biology—We're Open

Philip Bernstein, Barbara Cohen, Catriona MacCallum, Hemai Parthasarathy, Mark Patterson, Vivian Siegel

Essay

Neuroscience Networks

Thomas R Insel, Nora D Volkow, Ting-Kai Li, James F Battey Jr, Story C Landis

Features

Digital Evolution

Bill O'Neill

Journal Club

Heterochromatin Dynamics

Tobias Straub

Community Page

Out of the Way

Glenn Otis Brown

Research Articles

Drosophila Free-Running Rhythms Require Intercellular Communication

Ying Peng, Dan Stoleru, Joel D Levine, Jeffrey C Hall, Michael Rosbash

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A Functional Analysis of the Spacer of V(D)J Recombination Signal Sequences

Alfred Ian Lee, Sebastian D Fugmann, Lindsay G Cowell, Leon M Ptaszek, Garnett Kelsoe, David G Schatz

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Developmental Origin and Evolution of Bacteriocytes in the Aphid–Buchnera Symbiosis

Christian Braendle, Toru Miura, Ryan Bickel, Alexander W Shingleton, Srinivas Kambhampati, David L Stern

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Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions

Femke Simmer, Celine Moorman, Alexander M van der Linden, Ewart Kuijk, Peter V.E van den Berghe, Ravi S Kamath, Andrew G Fraser, Julie Ahringer, Ronald H. A Plasterk

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DNA Analysis Indicates That Asian Elephants Are Native to Borneo and Are Therefore a High Priority for Conservation

Prithiviraj Fernando, T. N. C Vidya, John Payne, Michael Stuewe, Geoffrey Davison, Raymond J Alfred, Patrick Andau, Edwin Bosi, Annelisa Kilbourn, Don J Melnick

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