Figures
Beware of crossing axons.
During development, growing axons frequently cross the midline of the body to connect the two sides of the nervous system. This process requires the Robo3 receptor, which is mutated in people suffering a rare congenital disorder. Conditional elimination of Robo3 from selected subsets of neurons in the mouse provides a model of this congenital strabismus and sheds light on the need for correct axon guidance in the development of specific behaviors (see Renier et al., e1000325).
Image Credit: Adrien Braure, modified by Alain Chédotal
Citation: (2010) PLoS Biology Issue Image | Vol. 8(3) March 2010. PLoS Biol 8(3): ev08.i03. https://doi.org/10.1371/image.pbio.v08.i03
Published: March 30, 2010
Copyright: © 2010 Renier et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
During development, growing axons frequently cross the midline of the body to connect the two sides of the nervous system. This process requires the Robo3 receptor, which is mutated in people suffering a rare congenital disorder. Conditional elimination of Robo3 from selected subsets of neurons in the mouse provides a model of this congenital strabismus and sheds light on the need for correct axon guidance in the development of specific behaviors (see Renier et al., e1000325).
Image Credit: Adrien Braure, modified by Alain Chédotal