Figures
Electron tomography of SARS-CoV–induced vesicular network of an infected cell.
Reticulovesicular network of modified endoplamic reticulum (ER) associated with severe acute respiratory syndrome (SARS)-coronavirus replication. Electron tomography was used to generate a three-dimensional reconstruction of the reticulovesicular network of modified ER induced in Vero E6 cells upon infection with SARS-coronavirus. SARS-coronavirus replication and transcription are associated with this membrane network, which is composed of a large number of conspicuous double membrane vesicles (outer membrane, gold; inner membrane, silver) of which the outer membranes are continuous with convoluted membranes (bronze) and ER cisternae. The surface-rendered model shown here is superimposed on a 1.2-nm-thick tomographic slice. (See Knoops et al., e226)
Image Credit: Illustration by Kèvin Knoops
Citation: (2008) PLoS Biology Issue Image | Vol. 6(9) September 2008. PLoS Biol 6(9): ev06.i09. https://doi.org/10.1371/image.pbio.v06.i09
Published: September 30, 2008
Copyright: © 2008 Kèvin Knoops. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Reticulovesicular network of modified endoplamic reticulum (ER) associated with severe acute respiratory syndrome (SARS)-coronavirus replication. Electron tomography was used to generate a three-dimensional reconstruction of the reticulovesicular network of modified ER induced in Vero E6 cells upon infection with SARS-coronavirus. SARS-coronavirus replication and transcription are associated with this membrane network, which is composed of a large number of conspicuous double membrane vesicles (outer membrane, gold; inner membrane, silver) of which the outer membranes are continuous with convoluted membranes (bronze) and ER cisternae. The surface-rendered model shown here is superimposed on a 1.2-nm-thick tomographic slice. (See Knoops et al., e226)
Image Credit: Illustration by Kèvin Knoops