Figures
Screening for morphological activity.
Clockwise to center: A library of small molecules (yellow) was screened using a cellmicroscopy-based assay to identify one with interesting biological activity. The protein it bound (and inhibited) was affinity purified, and its structure is shown in yellow. Solving the crystal structure of the small molecule/protein complex (bottom) informed the design of better inhibitors (gray).
Image Credit: Cover design by Daniel Rauh; molecular images created with PyMOL software; central fluorescence micrograph courtesy of Nico Stuurman. See Tanaka et al.
Citation: (2005) PLoS Biology Issue Image | Vol. 3(5) May 2005. PLoS Biol 3(5): ev03.i05. https://doi.org/10.1371/image.pbio.v03.i05
Published: May 31, 2005
Copyright: © 2005 Rauh, Stuurman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Clockwise to center: A library of small molecules (yellow) was screened using a cellmicroscopy-based assay to identify one with interesting biological activity. The protein it bound (and inhibited) was affinity purified, and its structure is shown in yellow. Solving the crystal structure of the small molecule/protein complex (bottom) informed the design of better inhibitors (gray).
Image Credit: Cover design by Daniel Rauh; molecular images created with PyMOL software; central fluorescence micrograph courtesy of Nico Stuurman. See Tanaka et al.