Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish

• Haibo Xie ,

  Contributed equally to this work with: Haibo Xie, Yunsi Kang

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft

  Affiliations Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China, Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China, Affiliated Hospital of Guangdong Medical University & Key Laboratory of Zebrafish Model for Development and Disease of Guangdong Medical University, Zhanjiang, China, Fang Zongxi Center, Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China

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• Yunsi Kang ,

  Contributed equally to this work with: Haibo Xie, Yunsi Kang

  Roles Conceptualization, Data curation, Methodology, Visualization, Writing – original draft

  Affiliations Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China, Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China, Fang Zongxi Center, Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China

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• Junjun Liu,

  Roles Investigation

  Affiliations Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China, Fang Zongxi Center, Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China

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• Min Huang,

  Roles Data curation, Investigation, Methodology

  Affiliation Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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• Zhicheng Dai,

  Roles Data curation, Writing – original draft

  Affiliation Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing China

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• Jiale Shi,

  Roles Investigation

  Affiliations Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China, Fang Zongxi Center, Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China

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• Shuo Wang,

  Roles Software, Visualization

  Affiliations Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China, Fang Zongxi Center, Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China

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• Lanqin Li,

  Roles Methodology

  Affiliations Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China, Fang Zongxi Center, Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China

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• Yuan Li,

  Roles Investigation

  Affiliations Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China, Fang Zongxi Center, Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China

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• Pengfei Zheng,

  Roles Methodology

  Affiliations Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China, Fang Zongxi Center, Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China

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• Yi Sun,

  Roles Investigation

  Affiliations Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China, Fang Zongxi Center, Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China

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• Qize Han,

  Roles Validation

  Affiliations Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China, Fang Zongxi Center, Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China

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• Jingjing Zhang,

  Roles Writing – review & editing

  Affiliations Affiliated Hospital of Guangdong Medical University & Key Laboratory of Zebrafish Model for Development and Disease of Guangdong Medical University, Zhanjiang, China, The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, China

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• Zezhang Zhu,

  Roles Writing – review & editing

  Affiliation Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing China

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• Leilei Xu,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing China

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• Pamela C. Yelick ,

  Roles Funding acquisition, Resources, Writing – review & editing

  * E-mail: pamela.yelick@tufts.edu (PCY); muqingcao@sjtu.edu.cn (MC); chengtian_zhao@ouc.edu.cn (CZ)

  Affiliation Department of Orthodontics, Tufts University School of Dental Medicine, Boston, Massachusetts, United States of America

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• Muqing Cao ,

  Roles Funding acquisition, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: pamela.yelick@tufts.edu (PCY); muqingcao@sjtu.edu.cn (MC); chengtian_zhao@ouc.edu.cn (CZ)

  Affiliation Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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•  [ ... ],
• Chengtian Zhao

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: pamela.yelick@tufts.edu (PCY); muqingcao@sjtu.edu.cn (MC); chengtian_zhao@ouc.edu.cn (CZ)

  Affiliations Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China, Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China, Fang Zongxi Center, Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China

  https://orcid.org/0000-0003-1236-914X

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