About the Authors

Daisuke Tone

Contributed equally to this work with: Daisuke Tone, Koji L. Ode, Qianhui Zhang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan, Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Koji L. Ode

Contributed equally to this work with: Daisuke Tone, Koji L. Ode, Qianhui Zhang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan, Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Qianhui Zhang

Contributed equally to this work with: Daisuke Tone, Koji L. Ode, Qianhui Zhang

Roles Data curation, Investigation, Methodology, Validation, Visualization

Affiliation Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Hiroshi Fujishima

Roles Investigation, Methodology, Resources, Validation

Affiliation Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan

Rikuhiro G. Yamada

Roles Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft

Affiliation Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan

Yoshiki Nagashima

Roles Investigation, Methodology, Validation

Affiliations Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, Thermo Fisher Scientific K.K., Yokohama, Kanagawa, Japan

Katsuhiko Matsumoto

Roles Investigation, Methodology, Validation

Affiliation Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan

Zhiqing Wen

Roles Investigation, Methodology, Validation

Affiliation Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Shota Y. Yoshida

Roles Investigation, Methodology, Validation, Visualization

Affiliations Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan, Graduate school of Medicine, Osaka University, Suita, Osaka, Japan

Tomoki T. Mitani

Roles Investigation, Methodology, Validation, Visualization

Affiliations Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan, Graduate school of Medicine, Osaka University, Suita, Osaka, Japan

Yuki Arisato

Roles Investigation, Methodology

Affiliations Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Rei-ichiro Ohno

Roles Investigation, Methodology, Resources

Affiliation Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Maki Ukai-Tadenuma

Roles Investigation, Methodology, Resources, Validation

Current address: International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Affiliation Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan

Junko Yoshida Garçon

Roles Methodology, Resources

Affiliation Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan

Mari Kaneko

Roles Methodology, Resources

Affiliation Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Chuo-ku, Kobe, Hyogo, Japan

Shoi Shi

Roles Methodology, Resources, Validation

Current address: International Institute for Integrative Sleep Medicine (IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan

Affiliations Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan, Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Hideki Ukai

Roles Investigation, Methodology, Resources, Validation

Current address: International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Affiliation Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan

Kazunari Miyamichi

Roles Methodology, Resources

Affiliation Laboratory for Comparative Connections, RIKEN Center for Biosystems Dynamics Research, Chuo-ku, Kobe, Hyogo, Japan

Takashi Okada

Roles Methodology, Resources

Affiliation Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, the University of Tokyo, Minato-city, Tokyo, Japan

Kenta Sumiyama

Roles Methodology, Resources

Current address: Laboratory of Animal Genetics and Breeding, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, Japan

Affiliation Laboratory for Mouse Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan

Hiroshi Kiyonari

Roles Methodology, Resources

Affiliation Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Chuo-ku, Kobe, Hyogo, Japan

Hiroki R. Ueda

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

uedah-tky@umin.ac.jp

Affiliations Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan, Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: H.R.U conducted a collaborative research project with Thermo Fisher Scientific Inc. Y.N. is an employee of Thermo Fisher Scientific, Inc. The company provided support in the form of salary for Y.N., and technical advice on the setup of mass spectrometers. However, the company did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.