Protein Aggregation and Protein Instability Govern Familial Amyotrophic Lateral Sclerosis Patient Survival

Qi Wang; Joshua L Johnson; Nathalie Y.R Agar; Jeffrey N Agar

doi:10.1371/journal.pbio.0060170

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Open Access

Peer-reviewed

Research Article

Protein Aggregation and Protein Instability Govern Familial Amyotrophic Lateral Sclerosis Patient Survival

Qi Wang,

Affiliations Department of Chemistry, Brandeis University, Waltham, Massachusetts, United States of America , Volen Center, Brandeis University, Waltham, Massachusetts, United States of America
⨯
Joshua L Johnson,

Affiliations Volen Center, Brandeis University, Waltham, Massachusetts, United States of America , Department of Biochemistry, Brandeis University, Waltham, Massachusetts, United States of America
⨯
Nathalie Y.R Agar,

Affiliation Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jeffrey N Agar

*To whom correspondence should be addressed. E-mail: agar@brandeis.edu

Affiliations Department of Chemistry, Brandeis University, Waltham, Massachusetts, United States of America , Volen Center, Brandeis University, Waltham, Massachusetts, United States of America
⨯

Protein Aggregation and Protein Instability Govern Familial Amyotrophic Lateral Sclerosis Patient Survival

Qi Wang,
Joshua L Johnson,
Nathalie Y.R Agar,
Jeffrey N Agar

Published: July 29, 2008
https://doi.org/10.1371/journal.pbio.0060170

About the Authors

Qi Wang

Affiliations Department of Chemistry, Brandeis University, Waltham, Massachusetts, United States of America , Volen Center, Brandeis University, Waltham, Massachusetts, United States of America

Joshua L Johnson

Affiliations Volen Center, Brandeis University, Waltham, Massachusetts, United States of America , Department of Biochemistry, Brandeis University, Waltham, Massachusetts, United States of America

Nathalie Y.R Agar

Affiliation Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Jeffrey N Agar

*To whom correspondence should be addressed. E-mail: agar@brandeis.edu

Affiliations Department of Chemistry, Brandeis University, Waltham, Massachusetts, United States of America , Volen Center, Brandeis University, Waltham, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JNA and NYRA conceived the hypotheses. QW and JNA designed the analysis. QW, JLJ, and JNA performed the analysis. QW and JNA wrote the paper.

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Amyotrophic lateral sclerosis
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Point mutation
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Protein aggregation
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Medical risk factors
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Toxicity
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Computer software
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Linear regression analysis
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Thermodynamics
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