A Competition between Stimulators and Antagonists of Upf Complex Recruitment Governs Human Nonsense-Mediated mRNA Decay

Guramrit Singh; Indrani Rebbapragada; Jens Lykke-Andersen

doi:10.1371/journal.pbio.0060111

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Open Access

Peer-reviewed

Research Article

A Competition between Stimulators and Antagonists of Upf Complex Recruitment Governs Human Nonsense-Mediated mRNA Decay

Guramrit Singh,

¤ Current address: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Affiliation Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America
⨯
Indrani Rebbapragada,

Affiliation Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America
⨯
Jens Lykke-Andersen

*To whom correspondence should be addressed. E-mail: Jens.Lykke-Andersen@colorado.edu

Affiliation Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America
⨯

A Competition between Stimulators and Antagonists of Upf Complex Recruitment Governs Human Nonsense-Mediated mRNA Decay

Guramrit Singh,
Indrani Rebbapragada,
Jens Lykke-Andersen

Published: April 29, 2008
https://doi.org/10.1371/journal.pbio.0060111

About the Authors

Guramrit Singh

¤ Current address: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Affiliation Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America

Indrani Rebbapragada

Affiliation Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America

Jens Lykke-Andersen

*To whom correspondence should be addressed. E-mail: Jens.Lykke-Andersen@colorado.edu

Affiliation Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

GS, IR, and JL-A conceived and designed the experiments. GS and IR performed the experiments. GS, IR, and JL-A analyzed the data. GS and IR contributed reagents/materials/analysis tools. GS and JL-A wrote the paper.

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