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Retraction

Retraction: Nanocurcumin Prevents Hypoxia Induced Stress in Primary Human Ventricular Cardiomyocytes by Maintaining Mitochondrial Homeostasis

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After publication of this article [1], concerns were raised about results presented in Figs 2–4 and 7–8, specifically:

  • In Fig 2A, the bottom right of the N+C Actin panel appears to have similar features to the top left of the H+C Actin panel, and the H+C Actin panel appears different to the H+C Merge panel.
  • In Fig 3B in lane 1 of the Ac-H4 panel, there are patterns in the background which appear highly similar.
  • Lanes 1–4 of the β-actin panel in Fig 4B appear similar to lanes 1–4 of the β-actin panel in Fig 8A when flipped horizontally and compressed.
  • In lanes 1 and 3 in the p53 panel of Fig 4B, there are patterns in the background which appear highly similar.
  • In Fig 7A:
    1. ○ There appears to be a vertical discontinuity between lanes 1 and 2 in the Hypoxia-mito panel.
    2. ○ The image background patterns in lane 1 in the H+C-mito and H+NC-mito panels appear blurred compared to the adjacent background areas.
  • In Fig 8A:
    1. ○ Across the Hypoxia panel, there are patterns in the background which appear highly similar.
    2. ○ There appears to be a vertical discontinuity between lanes 3 and 4 in the H+NC panel.
  • In Fig 8C:
    1. ○ Across the Hypoxia panel, there are patterns in the background which appear highly similar.
    2. ○ There appears to be a vertical discontinuity between lanes 5 and 6 in the H+NC panel.

The authors did not respond to editorial requests for a response and underlying data. In light of the above unresolved concerns that question the integrity and reliability of the reported results and conclusions, the PLOS One Editors retract this article.

All authors either did not respond directly or could not be reached.

Reference

  1. 1. Nehra S, Bhardwaj V, Ganju L, Saraswat D (2015) Nanocurcumin Prevents Hypoxia Induced Stress in Primary Human Ventricular Cardiomyocytes by Maintaining Mitochondrial Homeostasis. PLoS ONE 10(9): e0139121. https://doi.org/10.1371/journal.pone.0139121 pmid:26406246

Citation: The PLOS One Editors (2025) Retraction: Nanocurcumin Prevents Hypoxia Induced Stress in Primary Human Ventricular Cardiomyocytes by Maintaining Mitochondrial Homeostasis. PLoS ONE 20(2): e0319025. https://doi.org/10.1371/journal.pone.0319025

Published: February 4, 2025

Copyright: © 2025 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.