Intracellular accumulation of free cholesterol in macrophages triggers a PARP1 response to DNA damage and PARP1 impairs lipopolysaccharide-induced inflammatory response

• Kenneth K.Y. Ting,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Writing – original draft, Writing – review & editing

  Affiliations Department of Immunology, University of Toronto, Toronto, Ontario, Canada, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada

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• Hisham M. Ibrahim,

  Roles Formal analysis, Investigation

  Affiliations Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

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• Nitya Gulati,

  Roles Investigation

  Affiliation Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada

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• Yufeng Wang,

  Roles Investigation

  Affiliation Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada

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• Jonathan V. Rocheleau,

  Roles Supervision

  Affiliation Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada

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• Myron I. Cybulsky

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: myron.cybulssky@utoronto.ca

  ¶‡ Lead Contact

  Affiliations Department of Immunology, University of Toronto, Toronto, Ontario, Canada, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada

  https://orcid.org/0000-0002-1696-2867

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