Hydroxycamptothecin regulates scar formation of the filtration channel under scleral flap by inhibiting the proliferation of scleral fibroblasts

Hongwei Gu; Ya Liang; Yao Shen; Jie Shuai; Qiuli Yu; Huaijin Guan; Zhilan Yuan

doi:10.1371/journal.pone.0284618

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Open Access

Peer-reviewed

Research Article

Hydroxycamptothecin regulates scar formation of the filtration channel under scleral flap by inhibiting the proliferation of scleral fibroblasts

Hongwei Gu ,

Contributed equally to this work with: Hongwei Gu, Ya Liang, Yao Shen

Roles Conceptualization

Affiliations Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China, Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
⨯
Ya Liang ,

Contributed equally to this work with: Hongwei Gu, Ya Liang, Yao Shen

Roles Validation

Affiliation Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯
Yao Shen ,

Contributed equally to this work with: Hongwei Gu, Ya Liang, Yao Shen

Roles Data curation

Affiliation Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
⨯
Jie Shuai,

Roles Validation

Affiliation Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
⨯
Qiuli Yu,

Roles Formal analysis

Affiliation Department of Ophthalmology, Nanjing Medical University, The Second Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯
Huaijin Guan ,

Roles Supervision

* E-mail: zhilan_yuan@163.com (ZY); guanhj_eye@163.com (HG)

Affiliation Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
⨯
Zhilan Yuan

Roles Supervision

* E-mail: zhilan_yuan@163.com (ZY); guanhj_eye@163.com (HG)

Affiliation Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China

https://orcid.org/0000-0002-3223-8625

⨯

Hydroxycamptothecin regulates scar formation of the filtration channel under scleral flap by inhibiting the proliferation of scleral fibroblasts

Hongwei Gu,
Ya Liang,
Yao Shen,
Jie Shuai,
Qiuli Yu,
Huaijin Guan,
Zhilan Yuan

Published: April 20, 2023
https://doi.org/10.1371/journal.pone.0284618

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