Connecting real-world digital mobility assessment to clinical outcomes for regulatory and clinical endorsement–the Mobilise-D study protocol

• A. Stefanie Mikolaizak,

  Roles Conceptualization, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Department of Clinical Gerontology, Robert-Bosch-Hospital, Stuttgart, Germany

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• Lynn Rochester,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom

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• Walter Maetzler,

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – review & editing

  Affiliation Department of Neurology, University Medical Center Schleswig-Holstein, Kiel, Germany

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• Basil Sharrack,

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – review & editing

  Affiliation Department of Neuroscience and Sheffield NIHR Translational Neuroscience BRC, Sheffield Teaching Hospitals NHS Foundation Trust & University of Sheffield, Sheffield, England, United Kingdom

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• Heleen Demeyer,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliations Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium, Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium, Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium

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• Claudia Mazzà,

  Roles Funding acquisition, Investigation, Methodology, Writing – review & editing

  Affiliation Insigneo Institute, Department of Mechanical Engineering, University of Sheffield, Sheffield, United Kingdom

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• Brian Caulfield,

  Roles Data curation, Funding acquisition, Investigation, Project administration, Software, Writing – review & editing

  Affiliations Insight Centre for Data Analytics, O’Brien Science Centre, University College Dublin, Dublin, Ireland, UCD School of Public Health, Physiotherapy and Sports Science University College Dublin, Dublin, Ireland

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• Judith Garcia-Aymerich,

  Roles Data curation, Formal analysis, Funding acquisition, Methodology, Writing – review & editing

  Affiliations Barcelona Institute for Global Health (ISGlobal), Barcelona, Catalonia, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

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• Beatrix Vereijken,

  Roles Funding acquisition, Visualization, Writing – review & editing

  Affiliation Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway

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• Valdo Arnera,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Clario, Geneva, Switzerland

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• Ram Miller,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Novartis Institutes for Biomedical Research, Cambridge, MA, United States of America

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• Paolo Piraino,

  Roles Resources, Writing – review & editing

  Affiliation Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany

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• Nadir Ammour,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Clinical Science & Operations, Global Development, Sanofi R&D, Chilly-Mazarin, France

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• Mark Forrest Gordon,

  Roles Resources, Writing – review & editing

  Affiliation Specialty Clinical Development, Teva Pharmaceuticals, West Chester, PA, United States of America

  https://orcid.org/0000-0002-0271-3050

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• Thierry Troosters,

  Roles Funding acquisition, Investigation, Project administration, Writing – review & editing

  Affiliations Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium, Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium

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• Alison J. Yarnall,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom

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• Lisa Alcock,

  Roles Investigation, Software, Writing – review & editing

  Affiliation Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom

  https://orcid.org/0000-0002-8364-9803

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• Heiko Gaßner,

  Roles Data curation, Investigation, Project administration, Validation, Writing – review & editing

  Affiliation Department of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany

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• Jürgen Winkler,

  Roles Project administration, Resources, Writing – review & editing

  Affiliation Department of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany

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• Jochen Klucken,

  Roles Investigation, Project administration, Supervision, Writing – review & editing

  Affiliation Digital Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg

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• Christian Schlenstedt,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Neurology, University Medical Center Schleswig-Holstein, Kiel, Germany, Institute of Interdisciplinary Exercise Science and Sports Medicine, Medical School Hamburg, Hamburg, Germany

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• Henrik Watz,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Pulmonary Research Institute at LungClinic Grosshansdorf GmbH, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany

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• Anne-Marie Kirsten,

  Roles Investigation, Project administration, Writing – review & editing

  Affiliation Pulmonary Research Institute at LungClinic Grosshansdorf GmbH, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany

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• Ioannis Vogiatzis,

  Roles Funding acquisition, Investigation, Supervision, Writing – review & editing

  Affiliation Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle, England

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• Nikolaos Chynkiamis,

  Roles Investigation, Writing – review & editing

  Affiliation Thorax Research Foundation & First Dept. of Respiratory Medicine, National & Kapodistrian University of Athens, Sotiria General Chest Hospital, Athens, Greece

  https://orcid.org/0000-0002-9595-6974

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• Emily Hume,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle, England

  https://orcid.org/0000-0003-0462-2395

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• Dimitrios Megaritis,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle, England

  https://orcid.org/0000-0001-6786-4346

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• Alice Nieuwboer,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation KU Leuven, Department of Rehabilitation Sciences, Neurorehabilitation Research Group (eNRGy), Leuven, Belgium

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• Pieter Ginis,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation KU Leuven, Department of Rehabilitation Sciences, Neurorehabilitation Research Group (eNRGy), Leuven, Belgium

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• Ellen Buckley,

  Roles Data curation, Investigation, Project administration, Writing – review & editing

  Affiliations Department of Neuroscience and Sheffield NIHR Translational Neuroscience BRC, Sheffield Teaching Hospitals NHS Foundation Trust & University of Sheffield, Sheffield, England, United Kingdom, Insigneo Institute, Department of Mechanical Engineering, University of Sheffield, Sheffield, United Kingdom

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• Gavin Brittain,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Neuroscience and Sheffield NIHR Translational Neuroscience BRC, Sheffield Teaching Hospitals NHS Foundation Trust & University of Sheffield, Sheffield, England, United Kingdom

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• Giancarlo Comi,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliations Department of Neurology, San Raffaele University, Milan, Italy, Casa di Cura del Policlinico, Milan, Italy

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• Letizia Leocani,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Department of Neurology, San Raffaele University, Milan, Italy

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• Jorunn L. Helbostad,

  Roles Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway

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• Lars Gunnar Johnsen,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway

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• Kristin Taraldsen,

  Roles Conceptualization, Investigation, Supervision, Writing – review & editing

  Affiliations Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway, Department of Physiotherapy, Oslo Metropolitan University (OsloMet), Oslo, Norway

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• Hubert Blain,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Geriatrics, Montpellier University Hospital and MUSE, Montpellier, France

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• Valérie Driss,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Geriatrics, Montpellier University Hospital and MUSE, Montpellier, France

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• Anja Frei,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland

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• Milo A. Puhan,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland

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• Ashley Polhemus,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland

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• Magda Bosch de Basea,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Barcelona Institute for Global Health (ISGlobal), Barcelona, Catalonia, Spain

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• Elena Gimeno,

  Roles Investigation, Writing – review & editing

  Affiliation Barcelona Institute for Global Health (ISGlobal), Barcelona, Catalonia, Spain

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• Nicholas S. Hopkinson,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation National Heart and Lung Institute, Imperial College London, London, England

  https://orcid.org/0000-0003-3235-0454

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• Sara C. Buttery,

  Roles Investigation, Project administration, Writing – review & editing

  Affiliation National Heart and Lung Institute, Imperial College London, London, England

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• Jeffrey M. Hausdorff,

  Roles Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliations Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Department of Physical Therapy, Sackler Faculty of Medicine & Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, Rush Alzheimer’s Disease Center and Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America

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• Anat Mirelman,

  Roles Methodology, Project administration, Supervision, Writing – review & editing

  Affiliations Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Department of Physical Therapy, Sackler Faculty of Medicine & Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

  https://orcid.org/0000-0002-1520-2292

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• Jordi Evers,

  Roles Data curation, Funding acquisition, Resources, Software, Writing – review & editing

  Affiliation McRoberts BV, The Hague, Netherlands

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• Isabel Neatrour,

  Roles Data curation, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom

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• David Singleton,

  Roles Data curation, Methodology, Project administration, Software, Writing – review & editing

  Affiliations Insight Centre for Data Analytics, O’Brien Science Centre, University College Dublin, Dublin, Ireland, UCD School of Public Health, Physiotherapy and Sports Science University College Dublin, Dublin, Ireland

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• Lars Schwickert,

  Roles Methodology, Writing – original draft

  Affiliation Department of Clinical Gerontology, Robert-Bosch-Hospital, Stuttgart, Germany

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• Clemens Becker ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: clemens.becker@rbk.de

  Affiliation Department of Clinical Gerontology, Robert-Bosch-Hospital, Stuttgart, Germany

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• Carl-Philipp Jansen,

  Roles Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Department of Clinical Gerontology, Robert-Bosch-Hospital, Stuttgart, Germany

  https://orcid.org/0000-0002-2779-7019

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•  [ ... ],
• and members of the clinical validation study (WP4) on behalf of Mobilise-D consortium

  ¶Membership of the Mobilise-D consortium is provided in the Acknowledgments.

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