CDK4/6 inhibition synergizes with inhibition of P21-Activated Kinases (PAKs) in lung cancer cell lines

Gabriela M. Wright; Nick T. Gimbrone; Bhaswati Sarcar; Trent R. Percy; Edna R. Gordián; Fumi Kinose; Natália J. Sumi; Uwe Rix; W. Douglas Cress

doi:10.1371/journal.pone.0252927

Loading metrics

Open Access

Peer-reviewed

Research Article

CDK4/6 inhibition synergizes with inhibition of P21-Activated Kinases (PAKs) in lung cancer cell lines

Gabriela M. Wright,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Molecular Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Nick T. Gimbrone,

Roles Formal analysis, Investigation

Affiliation Department of Molecular Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Bhaswati Sarcar,

Roles Investigation

Affiliation Department of Molecular Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Trent R. Percy,

Roles Investigation

Affiliation Department of Molecular Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Edna R. Gordián,

Roles Investigation

Affiliation Department of Molecular Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Fumi Kinose,

Roles Data curation, Investigation, Methodology

Affiliation Department of Thoracic Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Natália J. Sumi,

Roles Investigation

Affiliations Department of Drug Discovery, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America, Cancer Biology PhD Program, University of South Florida, Tampa, Florida, United States of America
⨯
Uwe Rix,

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliation Department of Drug Discovery, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
W. Douglas Cress

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: Douglas.Cress@moffitt.org

Affiliation Department of Molecular Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

https://orcid.org/0000-0002-9119-3658

⨯

CDK4/6 inhibition synergizes with inhibition of P21-Activated Kinases (PAKs) in lung cancer cell lines

Gabriela M. Wright,
Nick T. Gimbrone,
Bhaswati Sarcar,
Trent R. Percy,
Edna R. Gordián,
Fumi Kinose,
Natália J. Sumi,
Uwe Rix,
W. Douglas Cress

Published: June 17, 2021
https://doi.org/10.1371/journal.pone.0252927

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Autophagic cell death
Is the Subject Area "Autophagic cell death" applicable to this article?

Thanks for your feedback.
Cell cycle and cell division
Is the Subject Area "Cell cycle and cell division" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Immunoblotting
Is the Subject Area "Immunoblotting" applicable to this article?

Thanks for your feedback.
Library screening
Is the Subject Area "Library screening" applicable to this article?

Thanks for your feedback.
Non-small cell lung cancer
Is the Subject Area "Non-small cell lung cancer" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.