Comparative Genomic, MicroRNA, and Tissue Analyses Reveal Subtle Differences between Non-Diabetic and Diabetic Foot Skin

Horacio A. Ramirez; Liang Liang; Irena Pastar; Ashley M. Rosa; Olivera Stojadinovic; Thomas G. Zwick; Robert S. Kirsner; Anna G. Maione; Jonathan A. Garlick; Marjana Tomic-Canic

doi:10.1371/journal.pone.0137133

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Peer-reviewed

Research Article

Comparative Genomic, MicroRNA, and Tissue Analyses Reveal Subtle Differences between Non-Diabetic and Diabetic Foot Skin

Horacio A. Ramirez,

Affiliations Human Genetics and Genomics Graduate Program in Biomedical Sciences, University of Miami Miller School of Medicine, Miami, FL, United States of America, Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School Of Medicine, Miami, FL, United States of America
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Liang Liang,

Affiliation Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School Of Medicine, Miami, FL, United States of America
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Irena Pastar,

Affiliation Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School Of Medicine, Miami, FL, United States of America
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Ashley M. Rosa,

Affiliation Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School Of Medicine, Miami, FL, United States of America
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Olivera Stojadinovic,

Affiliation Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School Of Medicine, Miami, FL, United States of America
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Thomas G. Zwick,

Affiliation University of Miami Hospital, UM Health System, Miami, FL, United States of America
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Robert S. Kirsner,

Affiliations Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School Of Medicine, Miami, FL, United States of America, University of Miami Hospital, UM Health System, Miami, FL, United States of America
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Anna G. Maione,

Affiliations Cell, Molecular, Developmental Biology, Tufts University, Sackler School of Graduate Biomedical Sciences, Boston, MA, United States of America, Department of Oral and Maxillofacial Pathology, Oral Medicine and Craniofacial Pain School of Dental Medicine, Tufts University, Boston, MA, United States of America
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Jonathan A. Garlick,

Affiliations Cell, Molecular, Developmental Biology, Tufts University, Sackler School of Graduate Biomedical Sciences, Boston, MA, United States of America, Department of Oral and Maxillofacial Pathology, Oral Medicine and Craniofacial Pain School of Dental Medicine, Tufts University, Boston, MA, United States of America
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Marjana Tomic-Canic

* E-mail: mtcanic@med.miami.edu

Affiliations Human Genetics and Genomics Graduate Program in Biomedical Sciences, University of Miami Miller School of Medicine, Miami, FL, United States of America, Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School Of Medicine, Miami, FL, United States of America
⨯

Comparative Genomic, MicroRNA, and Tissue Analyses Reveal Subtle Differences between Non-Diabetic and Diabetic Foot Skin

Horacio A. Ramirez,
Liang Liang,
Irena Pastar,
Ashley M. Rosa,
Olivera Stojadinovic,
Thomas G. Zwick,
Robert S. Kirsner,
Anna G. Maione,
Jonathan A. Garlick,
Marjana Tomic-Canic

Published: August 28, 2015
https://doi.org/10.1371/journal.pone.0137133

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Diabetes mellitus
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Epidermis
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Fibroblasts
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Wound healing
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Gene expression
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Keratinocytes
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MicroRNAs
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Ulcers
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