Irisin Induces Angiogenesis in Human Umbilical Vein Endothelial Cells In Vitro and in Zebrafish Embryos In Vivo via Activation of the ERK Signaling Pathway

Fei Wu; Haibo Song; Yuan Zhang; Yuzhu Zhang; Qian Mu; Miao Jiang; Fang Wang; Wen Zhang; Liang Li; Huanjie Li; Yunshan Wang; Mingxiang Zhang; Shiwu Li; Lijun Yang; Yan Meng; Dongqi Tang

doi:10.1371/journal.pone.0134662

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Peer-reviewed

Research Article

Irisin Induces Angiogenesis in Human Umbilical Vein Endothelial Cells In Vitro and in Zebrafish Embryos In Vivo via Activation of the ERK Signaling Pathway

Fei Wu,

Affiliation Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, 250012, P.R. China
⨯
Haibo Song,

Affiliation Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, 250012, P.R. China
⨯
Yuan Zhang,

Affiliation Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, 250012, P.R. China
⨯
Yuzhu Zhang,

Affiliation Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, 250012, P.R. China
⨯
Qian Mu,

Affiliation Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, 250012, P.R. China
⨯
Miao Jiang,

Affiliation Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, 250012, P.R. China
⨯
Fang Wang,

Affiliation Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, 250012, P.R. China
⨯
Wen Zhang,

Affiliation Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, 250012, P.R. China
⨯
Liang Li,

Affiliation Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, 250012, P.R. China
⨯
Huanjie Li,

Affiliation Jinan Central Hospital Affiliated to Shandong University, Jinan, 250012, P.R. China
⨯
Yunshan Wang,

Affiliation Jinan Central Hospital Affiliated to Shandong University, Jinan, 250012, P.R. China
⨯
Mingxiang Zhang,

Affiliation Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, 250012, P.R. China
⨯
Shiwu Li,

Affiliation Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, United States of America
⨯
Lijun Yang,

Affiliation Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, United States of America
⨯
Yan Meng ,

* E-mail: tangdq@sdu.edu.cn (DT); mengyan2000@126.com (YM)

Affiliation Department of Urology, The Second Hospital of Shandong University, Jinan, 250012, P.R. China
⨯
[ ... ],
Dongqi Tang

* E-mail: tangdq@sdu.edu.cn (DT); mengyan2000@126.com (YM)

Affiliation Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, 250012, P.R. China
⨯
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Irisin Induces Angiogenesis in Human Umbilical Vein Endothelial Cells In Vitro and in Zebrafish Embryos In Vivo via Activation of the ERK Signaling Pathway

Fei Wu,
Haibo Song,
Yuan Zhang,
Yuzhu Zhang,
Qian Mu,
Miao Jiang,
Fang Wang,
Wen Zhang,
Liang Li,
Huanjie Li

Published: August 4, 2015
https://doi.org/10.1371/journal.pone.0134662

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Angiogenesis
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Zebrafish
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ERK signaling cascade
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Endothelial cells
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Cell migration
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Coronary heart disease
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MAPK signaling cascades
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Extracellular matrix
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