About the Authors

Yuka Yagisawa

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan, Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, Japan

Kenji Suita

Roles Conceptualization, Formal analysis, Investigation, Methodology

Affiliation Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

Yoshiki Ohnuki

Roles Conceptualization, Investigation, Methodology

Affiliation Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

Misao Ishikawa

Roles Methodology

Affiliation Department of Oral Anatomy, Tsurumi University School of Dental Medicine, Yokohama, Japan

Yasumasa Mototani

Roles Investigation

Affiliation Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

Aiko Ito

Roles Investigation

Affiliation Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, Japan

Ichiro Matsuo

Roles Investigation

Affiliations Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan, Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, Japan

Yoshio Hayakawa

Roles Investigation

Affiliations Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan, Department of Dental Anesthesiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

Megumi Nariyama

Roles Investigation

Affiliation Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine, Yokohama, Japan

Daisuke Umeki

Roles Methodology

Affiliation Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, Japan

Yasutake Saeki

Roles Supervision

Affiliation Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

Yasuharu Amitani

Roles Formal analysis

Affiliation Department of Mathematics, Tsurumi University School of Dental Medicine, Yokohama, Japan

Yoshiki Nakamura

Roles Supervision

Affiliation Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, Japan

Hiroshi Tomonari

Roles Supervision

Affiliation Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, Japan

Satoshi Okumura

Roles Conceptualization, Formal analysis, Funding acquisition, Writing – original draft

okumura-s@tsurumi-u.ac.jp

Affiliation Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

Competing Interests

SO received funding from Pfizer Japan. There are no patents, products in development or marketed products to declare. This does not alter our adherence to PLoS One policies on sharing data and meterials.