About the Authors

O. Fernández

oscar.fernandez.sspa@gmail.com

Affiliation Hospitales Universitarios Regional de Málaga y Virgen de la Victoria, Universidad de Málaga, IBIMA

R. Arroyo

Affiliation Hospital U. Clínico San Carlos, Madrid

S. Martínez-Yélamos

Affiliation Hospital Universitario de Bellvitge, Barcelona

M. Marco

Affiliation Corporació Sanitaria Parc Taulí, Barcelona

J. A. García Merino

Affiliation Hospital Universitario Puerta de Hierro, Madrid

D. Muñoz

Affiliation Hospital Xeral Cies, Vigo

E. Merino

Affiliation Departamento Médico, Merck S.L

A. Roque

Affiliation Departamento Médico, Merck S.L

RELOAD Study Group

Membership of the RELOAD Study Group is provided in the Acknowledgments.

Competing Interests

OF and RA have received honoraria as consultants in advisory boards, and as chairmen or lecturer in meetings, and have also participated in clinical trials and other research projects promoted by Biogen-Idec, Bayer-Schering, Merck-Serono, Teva, Novartis, Genzyme, Roche, Allergan, and Almirall; S.M-Y has received honoraria compensation to participate in advisory boards, collaborations as a consultant and scientific communications from Biogen-Idec, Teva, Sanofi-Aventis, Merck-Serono, Novartis, and Bayer-Schering, and has received research support, funding for travel, and congress expenses from Biogen Idec, Teva, Sanofi-Aventis, Merck-Serono, Novartis, and Bayer-Schering; MM declares no conflict of interest; JAGM has received compensations for travel, lecturing or advisory work from Merck-Serono, Biogen-Idec, Bayer, Novartis, Almirall, Sanofi-Aventis, and research grants from Novartis and Biogen-Idec; DM has received honoraria as consultant in advisory boards, has participated and collaborated in meetings, and has also participated in clinical trials and other research projects promoted by Bayer-Schering, Merck-Serono, Novartis, Biogen-Idec, and Genzyme; EM and AR are employees at Merck-Serono. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: OF RA EM AR. Performed the experiments: OF RA SM-Y MM JAGM DM. Analyzed the data: OA RA EM AR. Wrote the paper: OF RA SMY MM JAGM DM EM AR.