About the Authors

Chen Shi

‡ The first two authors contributed equally to this work.

Affiliations Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China, Bioinformatics Center, School of Biomedical Engineering, Capital Medical University, Beijing, China

Zheng Zheng

‡ The first two authors contributed equally to this work.

Affiliation Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China

Qi Wang

Affiliation Department of Statistics, Purdue University, West Lafayette, Indiana, United States of America

Chaodong Wang

Affiliations Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China, Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China, Department of Neurology, The Affiliated Sanming First Hospital of Fujian Medical University, Sanming, Fujian, China

Dabao Zhang

Affiliations Bioinformatics Center, School of Biomedical Engineering, Capital Medical University, Beijing, China, Department of Statistics, Purdue University, West Lafayette, Indiana, United States of America

Min Zhang

zhangmin@ccmu.edu.cn (MZ); pbchan90@gmail.com (PC); xmwang@ccmu.edu.cn (XMW)

Affiliations Bioinformatics Center, School of Biomedical Engineering, Capital Medical University, Beijing, China, Department of Statistics, Purdue University, West Lafayette, Indiana, United States of America, Alzheimer Disease Center of Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China

Piu Chan

zhangmin@ccmu.edu.cn (MZ); pbchan90@gmail.com (PC); xmwang@ccmu.edu.cn (XMW)

Affiliations Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China, Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China, Key Laboratory on Neurodegenerative Disease of Ministry of Education and Key Laboratory on Parkinson’s Disease of Beijing, Beijing, China, Parkinson Disease Center of Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China

Xiaomin Wang

zhangmin@ccmu.edu.cn (MZ); pbchan90@gmail.com (PC); xmwang@ccmu.edu.cn (XMW)

Affiliations Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China, Parkinson Disease Center of Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CS DZ MZ PC XMW. Performed the experiments: ZZ CDW PC XMW. Analyzed the data: CS ZZ QW DZ MZ PC. Wrote the paper: CS DZ MZ PC XMW.