About the Authors

Niina M. Santio

Affiliations Section of Genetics and Physiology, Department of Biology, University of Turku, 20500 Turku, Finland, Drug Research Doctoral Programme, University of Turku, 20520 Turku, Finland

Sini K. Eerola

Affiliation Section of Genetics and Physiology, Department of Biology, University of Turku, 20500 Turku, Finland

Ilkka Paatero

Affiliation Institute of Biomedicine, Department of Medical Biochemistry and Genetics, University of Turku, 20520 Turku, Finland

Jari Yli-Kauhaluoma

Affiliation Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, 00014 Helsinki, Finland

Fabrice Anizon

Affiliations Institut de Chimie de Clermont-Ferrand, Université Clermont Auvergne, Université Blaise Pascal, 63000 Clermont-Ferrand, France, Centre National de la Recherche Scientifique, 63178 Aubiere, France

Pascale Moreau

Affiliations Institut de Chimie de Clermont-Ferrand, Université Clermont Auvergne, Université Blaise Pascal, 63000 Clermont-Ferrand, France, Centre National de la Recherche Scientifique, 63178 Aubiere, France

Johanna Tuomela

Affiliations Institute of Biomedicine, Department of Cell Biology and Anatomy, University of Turku, 20520 Turku, Finland, Pharmatest Services Ltd, 20520 Turku, Finland

Pirkko Härkönen

Affiliation Institute of Biomedicine, Department of Cell Biology and Anatomy, University of Turku, 20520 Turku, Finland

Päivi J. Koskinen

paivi.koskinen@utu.fi

Affiliation Section of Genetics and Physiology, Department of Biology, University of Turku, 20500 Turku, Finland

Competing Interests

Johanna Tuomela was employed by Pharmatest Services Ltd for a period during the study. There are no patents, products in development, or marketed products to declare. This does not alter JT's adherence to all the PLOS ONE policies on sharing data and materials. Pirkko Härkönen is a PLOS ONE Editorial Board member, but this does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PJK NMS PH. Performed the experiments: NMS SKE IP JT. Analyzed the data: NMS SKE IP JT PJK PH. Contributed reagents/materials/analysis tools: JYK FA PM. Wrote the paper: NMS PJK PH JT.