A Bipolar Clamp Mechanism for Activation of Jak-Family Protein Tyrosine Kinases

Open Access

Peer-reviewed

Research Article

Dipak Barua,

Affiliation Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America
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James R. Faeder,

Affiliation Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Jason M. Haugh

* E-mail: jason_haugh@ncsu.edu

Affiliation Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America
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Phosphorylation
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Dimerization
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Membrane receptor signaling
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SH2 domains
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Cell membranes
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Dimers
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Protein kinase signaling cascade
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Cell binding
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