Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

Thomas O'Hara; László Virág; András Varró; Yoram Rudy

doi:10.1371/journal.pcbi.1002061

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Research Article

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

Thomas O'Hara,

Affiliation Cardiac Bioelectricity and Arrhythmia Center, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, United States of America
⨯
László Virág,

Affiliation Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary
⨯
András Varró,

Affiliations Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary, Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary
⨯
Yoram Rudy

* E-mail: rudy@wustl.edu

Affiliation Cardiac Bioelectricity and Arrhythmia Center, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, United States of America
⨯

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

Thomas O'Hara,
László Virág,
András Varró,
Yoram Rudy

Published: May 26, 2011
https://doi.org/10.1371/journal.pcbi.1002061

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Two minor issues in the INaK model implementation.

Posted by MichaelClerx on 07 Mar 2024 at 11:08 GMT

There are two minor issues in the INaK model implementation. Neither has a significant effect on the model predictions under baseline conditions.

1. The equation for x1 should be x1 = a4 * a1 * a2 + b1 * b4 * b3 + a2 * b4 * b3 + b3 * a1 * a2, where the correction is the "b1" in the second term (the paper and code erroneously use a "b2" here).
2. The [H+] is set to 10^-7 [mM], i.e. 10^-10 [M] for a pH of 10. Presumably this should be 10^-4 [mM] for a pH of 7.

Full details are given in this google document: https://docs.google.com/d...

No competing interests declared.

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Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

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Two minor issues in the INaK model implementation.

Posted by MichaelClerx on 07 Mar 2024 at 11:08 GMT